Anti-Inflammatory and Analgesic Potential of Hot Water Extracts of Mulberry Leaves
Anti-Inflammatory and Analgesic Potential of Hot Water Extracts of Mulberry Leaves
Aamir Ali, Hafiz Muhammad Tahir*, Azizullah, Shaukat Ali, Muhammad Summer, Ali Haidar Gormani, Saira Nawaz and Ayesha Muzamil
ABSTRACT
Various diseases have been traditionally treated by utilizing different parts of mulberry plants. Mulberry leaves possess different physiological and biological potentials. Inflammation is the most common factor involved in various chronic diseases. This research study was conducted to evaluate anti-inflammatory and analgesic potentials of hot water extracts of mulberry leaves (mulberry tea) of two species i.e., Morus alba and Morus nigra. Mice were fed orally with mulberry leaves extract (200mg/kg, 100mg/kg and 50mg/kg) mixed in distilled water. Mice paw edema was induced by carrageenan injection while formalin was injected to mice paw for induction of pain. These extracts significantly decreased edema in mice paw. The level of TLC and RBCs was increased to normal. Platelets level was also increased in mice treated with mulberry leaves extracts. Furthermore, these extracts significantly reduced the inflammatory pain and licking response triggered by injection of formalin in mice paw. These findings showed that the hot water extracts of leaves of these two plant species possess analgesic and anti-inflammatory potentials.
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