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Application and Challenge of Nano-Systems against Intracellular Bacterial Infection

Application and Challenge of Nano-Systems against Intracellular Bacterial Infection

Xiaoli Cai1,2, Saeed Ahmed3, Zhixin Lei1,*, Jianping Wu1,* and Taolei Sun1,2,*

1School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, 122 Luoshi Road, Wuhan 430070, China
2State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, 122 Luoshi Road, Wuhan 430070, China
3Department of Biological Sciences, National University of Medical Sciences, Rawalpindi 46000, Pakistan
 
Zhixin Lei, Jianping Wu and Taolei Sun have contributed equally to this paper.
 
* Corresponding authors: Leizhixin@whut.edu.cn; suntaolei@iccas.ac.cn; biojpwu@whut.edu.cn

ABSTRACT

Intracellular pathogenic bacteria cause chronic, persistent and latent infections. The treatment for intracellular infection faces many challenges, such as targeting bacteria with antimicrobial drugs and resistance to multidrug (MDR). The present study delivers a possible elucidation to this problem via Nano Drug Delivery. Nanomaterials are relatively small as compared to ordinary antibiotics. The nanoparticle has unique physical and chemical properties, a large surface area, and an electric charge. Additionally, its antibacterial drug encapsulation can make it easier to enter the cell and improve the concentration in the target tissue. In the current review, the purpose is to find a more effective nanometer system to fight against intracellular bacterial infection. Current observation describes the drug resistance mechanism of bacteria, the bactericidal mechanism of antibiotics, the way of nanoparticles overpasses the cell membrane and approaching the cell, the strategies, prospects and challenges of nanoparticles treating intracellular bacteria.
 

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Pakistan Journal of Zoology

August

Vol. 54, Iss. 4, Pages 1501-2001

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