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Changes in Serum Endothelin, Brain Natriuretic Peptide and High Sensitive C-Reactive Protein Levels in Patients with Coronary Heart Disease

Changes in Serum Endothelin, Brain Natriuretic Peptide and High Sensitive C-Reactive Protein Levels in Patients with Coronary Heart Disease

Zheng Tan*, Li Li, Yuxin Song, Meirong Tian and Fan Jia

Second Department of Cardiovasology, Tangshan Gongren Hospital, Tangshan, 063000, China

 
* Corresponding author: profacademic33@gmail.com

ABSTRACT

In this study, 150 patients diagnosed with coronary heart disease (CHD) were divided them into three groups, each containing 50 patients, namely stable angina pectoris (SAP) group, unstable angina pectoris (UAP) group, and acute myocardial infarction (AMI) group. Fifth healthy people were enrolled as control. The changes in serum endothelin, brain natriuretic peptide and high sensitive c-reactive protein in patients with CHD were observed and analyzed. The levels of serum endothelin, brain natriuretic peptide and high-sensitivity c-reactive protein were significantly higher in AMI group compared to UAP group, SAP group and the control group, p<0.05. The level of indicators in the UAP group was higher than that in the SAP group and the control group, p<0.05. Compared with the control group, all indicators in SAP group were significantly higher, p<0.05. The serum endothelin, brain natriuretic peptide and high sensitive c-reactive protein levels were significantly increased during the clinical diagnosis of CHD, which indicates that these three indicators play a key role in the pathogenesis and can be used as indicators for clinical risk stratification of CHD.

 

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Pakistan Journal of Zoology

June

Vol. 54, Iss. 3, Pages 1001-1500

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