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In Vitro Antiviral Effect of Interferon Produced by Bovine Ephemeral Fever Virus against Rift Valley Fever Virus

In Vitro Antiviral Effect of Interferon Produced by Bovine Ephemeral Fever Virus against Rift Valley Fever Virus

Sahar M. Saber1*, Ahmed M. A. Albehwar2, Amani M. Abas3, Omaima A.A. Alshamandy2, Noha A. El said4 and Marwa Y. Hamad4

1Central Laboratory for Evaluation of Veterinary Biologics (CLEVB), Agricultural Research Center (ARC); 2Department of Pet Animal Vaccine Research (DPAVR), Veterinary Serum and Vaccine Research Institute (VSVRI), Abbasia, Cairo, Agricultural Research Center (ARC); 3Quality Control Laboratory (QCL), Vaccine Research Institute (VSVRI), Abbasia, Cairo, Agricultural Research Center (ARC); 4Department of Rift Valley Fever Research (DRFVR), Vaccine Research Institute (VSVRI), Abbasia, Cairo, Agricultural Research Center (ARC).

 
*Correspondence | Sahar M. Saber, Central Laboratory for Evaluation of Veterinary Biologics (CLEVB), Agricultural Research Center (ARC); Email: saharsaber71@gmail.com 

ABSTRACT

This work as an interesting one is a trial to prepare a natural economic antiviral agent against Rift Valley Fever virus which may be able to minimize the virus infection. This study was designed as a preliminary in vitro investigation of the effect of interferon-induced by bovine ephemeral fever virus (BEFV) in Madin-Darby Bovine Kidney (MDBK) and African green monkey kidney (Vero) cell cultures against RVFV. Such interferon was successfully obtained with high concentrations by both cell cultures up to a dilution of 10 -5 yielding positive antiviral effect against RVFV, especially when inoculated one hour post virus infection or simultaneously with the virus. So, we could conclude that the prepared interferon has an antiviral activity against RVFV and further studies are needed to provide more understanding of the virus-host interaction and cellular antiviral response and to evaluate the probable side effects of interferon on treated animals.

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Pakistan Journal of Zoology

February

Vol. 55, Iss. 1, Pages 1-500

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