Phylogenetic Analysis of Canine Distemper Virus in a Domestic Dog in Pakistan
Phylogenetic Analysis of Canine Distemper Virus in a Domestic Dog in Pakistan
Hasaan Aziz*, Fariha Altaaf, Attia Bashir, Abdul Basit, Syed Anam Masood Gardazi and Farah Haider
ABSTRACT
Canine distemper (CD), caused by canine distemper virus (CDV), is highly contagious disease of carnivores and is quite prevalent in Pakistan. The CDV is known to exist as 11 distinct clades around the globe; however, as to what prevail in Pakistan to devise appropriate diagnostics and control strategies is yet to be known. Despite the use of modified live vaccine to dogs, occurrence of disease is not uncommon. Here, we sequenced and phylogenetically analysed the complete hemagglutinin gene of CDV from a male dog (14 months old) exhibiting clinically suggestive symptoms. With a characteristic amino acid residue for dog at Y549, sequence analysis showed geographically distinct pattern clustering the study strain to clade Asia-2 but clearly distinct from vaccine strains. Though limited and preliminary data, the findings enhance our knowledge towards CDVs circulating in Pakistan. Further studies are much necessary to ascertain genetic characteristics of CDVs over a wide geographical area of the country together exploring the potential reasons of vaccine failure.
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