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Sero-Biochemical and Cardiac Morphological Alterations in Broiler Chicken Triggered by Dietary Dexamethasone

Sero-Biochemical and Cardiac Morphological Alterations in Broiler Chicken Triggered by Dietary Dexamethasone

Rafiqul Islam1, Nasrin Sultana1*, Md. Abu Hadi Noor Ali Khan2 

1Department of Anatomy and Histology, Bangladesh Agricultural University, Mymensingh, Bangladesh; 2Department of Pathology, Bangladesh Agricultural University, Mymensingh, Bangladesh.

*Correspondence | Nasrin Sultana, Department of Anatomy and Histology, Bangladesh Agricultural University, Mymensingh, Bangladesh; Email: nsultana.bau@gmail.com, nasrin.sultana@bau.edu.bd 

ABSTRACT

Glucocorticoid hormone is vital for the development of the fetal heart, but overexposure can harm adult cardiovascular health. Dexamethasone (DEX) is a widely administered synthetic glucocorticoid. The focus of this study was determining how DEX affects serum biochemistry (cholesterol and triglycerides), morphology, and morphometry of broiler hearts. Eighty one-day-old chicks (DOCs) were randomly categorized into four groups i.e., one control group and three trial groups (i.e., E1, E2, and E3). The control group was given commercial broiler feed and the trial groups were given commercial broiler feed containing DEX at the rate of 3, 5, and 7 mg/kg respectively for 28 days. On days 7, 14, 21, and 28 of the trial, blood and heart samples were collected. The serum cholesterol and triglycerides levels were determined. The heart specimens were prepared for histomorphological examination after the gross morphologic and morphometric (weight, length, and width) examination. Results indicated that the DEX treated broilers had significantly higher serum cholesterol and triglyceride levels than the control broilers. In the gross morphologic and morphometric examination, the DEX supplemented groups showed varying degrees of congestion and significant decrease in all parameters of heart. The histomorphological examination showed myofibrillar degeneration and vacuolation in the DEX groups with an extensive degree at days 21 and 28 of the trial. It can be concluded that the DEX treatment affect the serum biochemical markers as well as the morphologic and morphometric parameters of the broiler heart.

Keywords | Dexamethasone, Broiler, Heart, Biochemistry, Morphometry 

 

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Advances in Animal and Veterinary Sciences

June

Vol. 10, Iss. 6, Pages 1189-1422

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