Mudasir Irfan Dar*, Fareed Ahmad Khan and Farha Rehman
E-mail | irfanmudasir@gmail.com
...em and MDA, but provoked oxidative stress when applied at high dosages. Therefore, pesticide application at high concentrations can be considered as a kind of stress, similarly to other stresses such as salt, drought and low or high temperatures....
Laila M. Fadda1, Nouf M. Al-Rasheed1, Iman H. Hasan1, Hanaa M. Ali2,3*, Nawal M. Al-Rasheed1,4, Musaed Al-Fayez5, Aly M. Ahmed5, Nada Almutlaq1, Nehal Qasem1 and Reem Khalaf1
...induced by inflammation, oxidative stress in response to APAP toxicity in rats. Serum aminotransferases (ALT and AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), total protein, total bilirubin, hepatic glutathione (GSH), nitric oxide (NO), superoxide dismutase (SOD) and lipid peroxides (LP) levels were estimated. Moreover these biochemical parameters were confirmed by histopathological examination using hemotoxylin and eosin (H&E) and Mason t...
Mostafa A. Abdel-Maksoud1,2, Fathy A. Abdel-Ghaffar2, Azza El-Amir2, Gamal Badr3 and Saleh Al-Quraishy1*
G.E. Odo1*, E.J. Agwu1, N.I. Ossai2, C.O. Ezea3, J. Madu1 and V. Eneje2
... behaviour, haematology, oxidative stress biomarkers and biochemistry of African catfish (C. gariepinus) juvenile on days 7, 14, 21 and 28. Fish were exposed to 0.175, 0.0875 and 0.035 mg/L corresponding to 1/10, 1/20 and 1/50 of the 96 h LC50 value (1.75) of the pesticide. Behavioral responses which include colouration of the fish skin and opercula colouration were observed. Aluminium phosphide elicited effects on the haematological parameters of the fish suc...
Shazia Irfan1*, Asima Rani1, Muhammad Arshad2 and Razia Bashir1
...als and minerals creates oxidative stress may play some role in progression and pathogenesis of RA. The objective of this study was to investigate the role of Superoxide dismutase 1 (SOD1) gene polymorphism [rs2070424 (–251A/G)] in RA and to compare the levels of metals and minerals among its various genotypes in RA patients. A total of 400 individuals including age and gender matched healthy individuals (control group) and RA patients were genotyped. De...
Sidra Ilyas1, Abdul Rehman1* and Qasim Ilyas2
Baohua Chen1,2, Wenzhu Peng3, Jian Xu2, Jingyan Feng1,2, Chuanju Dong1,2 and Peng Xu2,3,*
...lular detoxification and oxidative stress tolerance. Comparing with that in mammals, investigation of GSTs is more complicated in teleosts because of the greater pressure they suffer in aquatic environment. In this study, we identified a set of 27 GSTs including 8 classes of members in common carp genome. Both sequences alignment and phylogenetic analysis exhibited that genes derived from the same GST class from different species share more similarity than gen...
Soraya Khosravian Dehordi*, Abdolnaser Mohebbi and Kahin Shahanipour
...fects. The generation of oxidative stress creates by the common mechanism their carcinogenicity and toxicity. The present study was planned to determine whether an oral administration of nano-selenium (nano-Se) influencing on biomarkers of oxidative status in the rats spleen exposed to the cadmium (Cd) metal. For this purpose, thirty male rats equally divided into six groups, group I received nano-Se (0.1mg/kg) alone as dose, group II selenite odium (0.1mg Se/...
Nazish Shaukat1, Muhammad Javed1,Faiza Ambreen2* and Fariha Latif1
...re important inducers of oxidative stress in aquatic animals, promoting the formation of reactive oxygen species (ROS) which ultimately leads to tissue damage and oxidation of biomolecules. Aquatic organisms possess antioxidant system to cope with the oxidative stress. This research was conducted to see the effect of lead on peroxidase activity (antioxidant enzyme) in the gills and liver of Labeo rohita. Experiment wa...
Kaori Sasaoka1, Takahiro Kataoka1, Norie Kanzaki1, Yusuke Kobashi1, Akihiro Sakoda2, Yuu Ishimori2 and Kiyonori Yamaoka1,*
...nephrotoxicity caused by oxidative stress. Here, we investigated whether radon inhalation has different effects against CDDP-induced renal injury in two mouse strains differing in radiosensitivity, and determined the appropriate dose of CDDP combined with radon inhalation for highly radiosensitive mice. CDDP was administered at 20 mg/kg weight to C57BL/6J and BALB/c mice after radon inhalation at 1000 Bq/m3 and 2000 Bq/m3 for 24 h. Radon ...
Fazul Nabi1,2, Hui Zhang1, Muhammad Kashif Iqbal1 , Mujeeb ur Rehman1, Muhammad Shahzad3, Khalid Mehmood1,3 and Jiakui Li1,*
...rowth plate width, liver oxidative stress and toxicity in avian TD. One hundred and fifty broiler chicks were equally distributed into three groups: Control, Thiram (50 mg/kg/d) and SM (10 mg/kg/d) treated. Results showed that thiram caused lameness, decrease in alkaline phosphatase (ALP) activity and increase in alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities in the serum along with decrease in level of antioxidant enzymes and s...
Ä°nan Kaya1,*, Muhitdin Yılmaz2, Müge MavioÄŸlu Kaya3,Abdulsamed Kükürt4 and Mahmut Karapehlivan5
...dy is to investigate the oxidative stress index in Capoeta capoeta treated with carbaryl and 2,4-dichlorophenoxyacetic acid (2,4-D). Fifty Capoeta capoeta fish caught in Kars Creek were equally divided into five groups and acclimatized in separate tanks for 10 days. The fish were kept in tanks as follows: Group I (control) was kept in normal water. Group II, III, IV and V were kept in separate tanks containing 0.3 mg/L carbaryl, 0.6 mg/L carbaryl...
Ashraf M. Mounir, A.N. El shahat* and A.M. Abdul Azeem
...rats resulted in cardiac oxidative stress, inflammation, hyper-lipidemia and increase cardiac marker enzymes. Treatment of rats with GFAE (45 mg/kg/day) prior to injection of ISO provide significant cardio-protective effects evidenced by an obvious reduction in the level of cardiac marker enzymes, inflammatory factors and lipid contents with marked improvement in the cardiac antioxidant status and reduction of lipid peroxidation relative to untreated in...
Tünay KontaÅŸ AÅŸkar1,*, Åžinasi AÅŸkar1, Olga Büyükleblebici2 and Murat Güzel3
...tudy is to determine the oxidative stress and inflammatory changes in naturally occurring canine visceral leishmaniasis (CVL). A total of 30 dogs, comprising 10 clinically healthy and 20 dogs with leishmaniasis were enrolled in this study. The diagnosis of canine visceral leishmaniasis was performed by the immune fluorescence antibody test with antibody titter ≥1:128 and lymph node smear examination. In blood samples of dogs with visceral leishmaniasis, lev...
Tahir Abbas*1, Khawaja Raees Ahmad2, Asmatullah3, Khalid Pervaiz Lone4, Muhammad Ali Kanwal2, Sadia Suleman2
Reno-hepatic protective effects of Jambul against chromium induced anomalies in mice
...d chain might be causing oxidative stress. That study was conducted to evaluate the protective effects of Jambul (Syzygium cumini) against Cr induced reno-hepatic anomalies. Male albino mice (Mus musculus) were equally divided (n=10) as C; control, Cr-treatedandCr-JgroupsreceivingCr+6 in the form of potassium dichromate (K2Cr2O7) 50ppm for 10days ad-libitum while Cr-J group additionally given 0.25ml/12h Jambul Fruit Extract (JFE) for next 5days by oral gavage....
Xu Lijie, Obaid Ullah, Liu Haixing, Ihsan Ali, Zhongshu Li* and Nan-Zhu Fang*
...can reduce intracellular oxidative stress during in vitro development by promoting the expression of antioxidant genes and suppressing the expression of NADPH oxidant genes....
Iqra Jaffar, Zainab Sehzadi, Muhammad Adeel, Khalid P. Lone and Mehwish Faheem*
...) for 7 days to evaluate oxidative stress in liver and gills by analyzing activity of glutathione-S-transferase (GST), catalase (CAT), glutathione (GSH) and by measuring lipid peroxidation (LPO). Catalase activity increased significantly in liver and gills of fish exposed to 10μg/l of DBP. Level of GSH and LPO increased significantly in gills while a non-significant decrease was recorded for GSH and GST in liver. These results showed that exposure to low co...
Xiaona Cao1,3-5, Yuanyuan Ren2-5, Xiaoteng Cui2-5, Baoxin Qian2-5, Chunyan Zhao 2-5, Jie Yang2-5, Chao Su2-5,* and Xingjie Gao2-5,*
... during arsenite induced-oxidative stress. Increased hnRNP A1 fluorescence signal within cytoplasm was detected from 3% of normal cells to the 28% of stressed cells; in contrast, 87% of cells with strong hnRNP A1 signal within nucleus reduced to 50% during stress. In addition, transport receptor importin-β pathway seems to be involved in the nuclear import of hnRNP A1, rather than HuR and TIA1. However, the slightly enhanced cytoplasmic accumulatio...
Muhammad Naveed Sheas1, Haris Rasool2, Muhammad Nouman Rafique2, Muhammad Rizwan Tariq1*, Abid Muhammad1, Khubaib Ali1
...chanisms of body against oxidative stress which is a key factor in elevating depression. This study is designed to reveal the efficacy of honey and curcumin against depression in rat model. 24 male wister rats were randomly divided into 4 groups. After the trial, blood biochemistry was done in which antioxidant enzymes like SOD, Catalyze, Glutathione peroxidase were performed that shows significantly high levels in the blood than the group that was treated wit...
Uzma Jabeen1, Irfan Khan2, Nadia Naeem2, Asmat Salim2,* and Waseem Ahmed1
...e induced in response to oxidative stress in heart and liver tissues following DOX administration to rats. In this study, DOX was administered to rats intraperitoneally (i. p.) at 3 mg/kg at alternate days for two weeks. Heart and liver tissues were harvested and the mRNA levels of NAD(P)H quinone dehydrogenase 1 (Nqo1), glutathione peroxidase (Gpx1) and isocitrate dehydrogenase-1 (Idh1) were analyzed by RT-PCR. We observedvariable pattern of gene expression w...
Chukwuemeka Calistus Okolo1*, Ikenna Onyema Ezeh2, Chinelo Nnenna Uju3 and Nwakaego Ernestina Nweze1
... haematobiochemical, and oxidative stress markers were determined. At day 13 PS, there were no significant (p< 0.05) variations in mean parasitaemia of groups A, B and D. At day 16 PS, the parasites had cleared from the peripheral blood of rats in groups A and B, but remained detectable in group D. Although group D had significantly higher total erythrocyte count and haemoglobin concentration compared to groups A--C, and E, no significant variation was seen...
Nouf Alharbi*, Mai Elobeid and Promy Virk
...ium-induced toxicity and oxidative stress in a male Sparaque Dawley rat model. There were four experimental groups with 6 rats in each: Group I control orally received normal saline, Group II orally administrated cadmium chloride (5 mg/kg bw/d), Group III orally administrated cadmium chloride (5mg/kg bw/d) and treated with low dose of quercetin (50 mg/kg bw/d), Group IV orally administrated cadmium chloride (5mg/kg bw/d) and treated with high dose of quercetin...
Sabbah M. Allam, T.M. El-Bedawy, M.H. Bakr and A.E.M. Mahmoud*
...garded as a biomarker of oxidative stress in cows, was insignificantly (P>0.05) affected by feeding experimental rations and ranged from 0.420 to 0.433 mm/l. Salmonella spp. was not detected and E. coli was insignificantly (P>0.05) affected by feeding DOP rations. It could be concluded that DOP can be used as an alternative source of energy in Holstein dairy cow’s rations, replacing up to 75% of yellow corn grains without negatively e...
Nosheen1, Sajid Abdullah1, Huma Naz2* and Khalid Abbas1
...tic system and can cause oxidative stress in fish. Evaluation of antioxidant in fish can reveal metal toxicity in the water ecosystem. Therefore, this experiment was planned to assess the acute affect of lead (Pb+2) on peroxidase (POD) activity in tissues viz. liver, gills, kidney, muscle, heart and brain of fish Catla catla exposed for 4-day. After each sampling (24-hr interval) fish were dissected and required organs were obtained. Results showed that the PO...
Fariha Latif1*, Muhammad Javed2, Hammad Ahmad Khan2 and Khalil-Ur-Rehman3
...b on bioaccumulation and oxidative stress in the liver, kidney, gills, muscles and brain of Cirrhina mrigala. The 120-days old fish were exposed to 1/4th (11.81mgL-1) and 2/3rd (31.49mgL-1) of 96-h LC50 of water-borne Pb for three fortnights (42 days) in glass aquaria at pH 7.5, temperature 30°C and total hardness 250mgL-1. After each fortnight, fish were sampled from each treatment a...
Saman Muhsin Abdulkareem* and Nadir Mustafa Nanakali
...re studied on indices of oxidative stress, liver enzymes activity and the expression of cytochrome P450 1A1 (CYP1A1) against hepatotoxicity induced by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) in male rat. Thirty adult male Wistar rats randomly divided into five equal groups. TCDD and QCT were orally administered at the dose of 10µg/kg /day and 20 mg/kg/day, respectively by gavage dissolved in corn oil for 90 days. At the end of the study, ani...
Dilara Abbas Bukhari*, Mehwish Faheem, Shamoona Arshad and Khalid P. Lone
...e determined to evaluate oxidative stress while urea and creatinine, was used to evaluate kidney function. It was found that there was an increase in weight (p<0.05) of both males and female mice fed with diet containing ghee. Kidney LPO and CAT were significantly increased in both male and female mice. GSH level showed decreasing trend in female while increase was observed for male kidney. Creatinine level increased in both male and female experimental gro...
Fatima Hashim Abbas1,2* and Alaa Tareq Shakir Al-Hassnawi1
...eased the level of serum oxidative stress (MDA) and this elevation may be driving the detrimental effects induced by parasitic or vial infections.
...
Aamir Mushtaq1,2, Rukhsana Anwar1 and Mobasher Ahmad1,2,*
...ry in mice by preventing oxidative stress in brain.
...
Alicja Kowalczyk1, Marian Kuczaj2, Anna Szul3 and Ewa Czerniawska-PiÄ…tkowska4*
Yuhong Li1, Dongxue Wu1, Xue Wang1, Mi Zhang1, Hanyu Zhu1, Zhe Shi1 and Fumin Feng1,2*
...creased, suggesting that oxidative stress reaction occurred in all drug groups. Compared with the baseline group, the mRNA and protein levels of NF-κB and TNF-α in the H group showed an increasing trend, and p-NF-κB and p-IκB also showed an increasing trend. However, these indicators increased first and then slightly decreased in the R, Z and HRZ groups. Among them, the significant changes in the indicators of the HRZ group were earlier...
Rubina Munir1,2*, Muhammad Zia-ur-Rehman3, Muhammad Makshoof Athar1, Noman Javid1,4, Ayesha Roohi2 and Syeda Fatima Razavi2
Yaqiu Liu1, Zhijian Wang 2, Xinhui Li 1*, Jianrong Zhao2 and Weitao Chen 1
...e: small;">The effect of oxidative stress on gill and gut enzyme activity in Paramisgurnus dabryanus was studied under different breathing restraint treatments. A total of 150 healthy mature individuals (mean initial body weight = 16.1 ± 3.7 g and mean initial total fork length = 13.1 ± 1.2 cm) were selected for the experiment. The experimental specimens were separated into three modes: control group (n = 50) without any stress treatments;...
Adnan Khan1, Rifat Ullah Khan1, Muhammad Subhan Qureshi2, Muhammad Mobashar3, Ali Gohar4, Shakoor Ahmad1, Kamran Khan5, Hamayun Khan1 and Shabana Naz6*
...T1 due to cryo shock and oxidative stress respectively. Sperm DNA integrity and pH were increased linearly from T1 to T3. The dead sperm percentage was significantly (P<0.01) low in groups with semen sample treated with T2 compared to other groups. Significantly (P<0.01) high sperm individual motility percentage was observed for T2 than T3 and T1. Sperm acrosomal integrity percentage showed significantly ((P<0.01) high value in T2. It is concluded tha...
Naveed Akhtar1*, Muhammad Fiaz Khan1*, Sadia Tabassum1,
Munawar Saleem Ahmad2 and Khan Dil Badshah3
...and muscles related with oxidative stress damage was observed. Genotoxicity increased with increase in time and concentration of cypermethrin. Cypermethrin is therefore extremly harmful to aquatic life.
...
Ying Liu1, Shankun Liu1, Hui Wang2 and Weihua Su2,*
...ncrease the incidence of oxidative stress. Caffeic acid is a powerful free radical scavenger and possesses antioxidant effect against the various diseases. Previous study suggests that the caffeic acid have potent anti-inflammatory activity. The aim of the current study was to scrutinize the protective effect of caffeic acid against the streptozotocin induced GDM in rats and explores the possible mechanism of action. A total 36 female rats were caged into the ...
Eman A. Al-Shahari1,2, Abdelhalim A. Alkhazendar3, Eman R. ElBealy4 and Abeer A. Alm-Eldeen3*
...tions via increasing the oxidative stress. Quercetin, a polyphenolic, that has antioxidant activity. Therefore, this study was performed to examine the possible role of quercetin in modulating aging-induced testicular damage. Samples from 30-months old rats’ testis were examined before and after 200 mg of quercetin/Kg administration. Before quercetin administration, they showed an increase in the lipid peroxidation and 8-hydroxy-2’-deoxyguanosine w...
Alamaary Mohaammed Saad1,3, Abd Wahid Haron1*, Mohamed Ali2,
Mark Wen Han Hiew1 and Lawan Adamu1
...a are susceptible to the oxidative stress OS during cryopreservation. The excessive reactive oxygen species (ROS) and the capacity of the antioxidants could affect the OS level in the frozen semen. This study was to determine the addition of different concentrations of antioxidants to evaluate oxidative stress and fertility of frozen semen in horses. Seven stallion were used for semen collection in this study. A total of twe...
Yawang Sun, Yongjiang Wu, Jingbo Chen, Zili Wang, Juncai Chen, You Yang and Guozhong Dong*
...>This study investigated oxidative stress and the consequent DNA damage induced by lipopolysaccharide (LPS) in bovine mammary epithelial cell line MAC-T cells. Cells were cultured for 48 h with different LPS levels (0, 0.1, 0.5, 2.5, 12.5, and 100 ng/mL). The results showed that cell viability was negatively correlated with LPS concentrations. The production of reactive oxygen species increased in a dose-depend manner. Cellular concentrations of oxidative dama...
Nashwa M. Helmy1, Ahmed S. Ahmed2, and Zeinab3 Y. Mohamed
...th LSD exposed to strong oxidative stress so recommended to use antioxidants in infected animals during treatment....
Aliya Munir1, Sajid Abdullah1*, Huma Naz2*, Khalid Abbas1, Tanveer Ahmed3 and Zahid Farooq2
Wenjuan Yan1, Qunlan Zhou2, Bo Liu2,3*, Cunxin Sun2, Huimin Zhang3 and Changyou Song2
...wn, reduce the damage of oxidative stress.
...
Mengke Wang1, Shucheng Huang2, Cai Zhang1*, Haizhou Gong1,
Shunan Cuan1, Shuaishuai Wang1, Qi Shao1, Wenhao Xu1, Sudan Meng1,
Pengfei Li1, Yuqin Wang1 and Zijun Yang1
...ing free radical-induced oxidative stress, which can cause considerable injury to commercial laying hens. However, the effects of monoammonium-glycyrrhizinate in improving liver lipid metabolism and antioxidant capacity of laying hens is unclear. The current study examined the ameliorative effects of monoammonium-glycyrrhizinate (MAG) on liver lipid metabolism and antioxidant capacity in laying hens. One hundred eighty 320-day-old Hy-Line brown laying hens wer...
Muhammad Aftab1*, Aneela Riaz2, Ghulam Sarwar3, Muhammad Arif1, Qudsia Nazir1, Ifra Saleem1, Sarfraz Hussain1, Abid Ali4, Abid Niaz1, Fakhar Mujeeb4, Khalid Mahmood5 and Sarfraz Nawaz6
...s of (B and Salt) causes oxidative stress in plants due to increase in production of the reactive oxygen species (ROS) including hydroxyl radicals (OH-), hydrogen peroxide (H2O2) and superoxide (O2-). However, on their side, efficient antioxidant defense system developed in plants, which having lower molecular weight of antioxidants. It also reduces (ROS) enzymatic activities including catalase (CAT), peroxidase (POD) and superoxide dismutase (SOD). Under comb...
Muhammad Shahbaz1,2, Sajid Abdullah1*, Huma Naz3*, Khalid Abbas1, Tanveer Ahmed4, Sana Mehmood1, Muhammad Adeel Hussan5
...e impact of Vitamin E on oxidative stress enzyme (catalase) of fish. Vitamin E has proven beneficial in protecting cellular membranes against oxidation and increases the resistance to stress.
Amr N. El-Shahat1, Refaat G. Hamza1,*, Ashraf M. Mounir1 and Madeha N. Al-Seeni2
...gainst radiation induced oxidative stress and biochemical alterations in the liver and kidney of male albino rats.In the present study, gamma- irradiation (2 Gy every 3 days up to 8 Gy total doses) induced biochemical and oxidative damage in rats when compared to control group. In GFJ (10ml/Kg B Wt. /day) treated irradiated group, there were noticeable decreases recorded in lipid contents, concentration of serum urea, creatinine and uric acid, glucose level, a...
Abdullah Abdo Albegali1, Tayyaba Aftab1, Atiq-ur-Rehman1*, Amir Rashid1 and Mayada Mohammad1,2
...cations, blood pressure, oxidative stress and haematological disorders. This study was done in the investigation of antihyperlipidemic effects of methanol extract of seeds of this plant in hyperlipidaemia Wistar albino rats induced by Triton X-100. There were 4 groups of rats: Group A served as normal; Group B, C and D were given high cholesterol diet and administered with intraperitoneal injection of Triton X-100 to induce hyperlipidaemia. Group B was adminis...
Faryal Malik, Mudassar Nawaz Khan* and Israr-ud-Din
...wheat varieties suffered oxidative stress due to flooding but showed a recovery trend due to increased activities of antioxidant enzymes that scavenged the oxidative radicles, thus helping the wheat to recover. Atta Habib reflected higher recovering ability than Siran and Ghanimat-e-IBGE. The findings of the current study will surely help in contributing efforts to develop flood-tolerant cultivars....
Syukriah Syukriah1, Ulinnuha Nur Faizah2, Hendry T.S. Saragih3*, Rizki Fitrawan Yuneldi4, Soenarwan Hery Poerwanto5, Raden Roro Upiek Ngesti Wibawaning Astuti5, Stephan Immenschuh6
... examined differences in oxidative stress-mediated effects in pregnant and offspring mice in Plasmodium berghei infection. A Complete randomized design was used in this study, in which 25 mice were divided into five groups. Group 1 as a control group, consisted of non-pregnant and Plasmodium-uninfected mice, group 2 comprised pregnant and uninfected mice, group 3 to 5 were pregnant mice and were infected with 1 x 101iRBCs, 1 x 102 iRBCs, and 1 x 103 iRBCs resp...
Hong Yin*, Dan Yang, Ji-Jie Liu, Jing-Wei Ding and Dan-Dan Cui
... through controlling the oxidative stress and balancing the level between FAS and acetyl-CoA carboxylase (ACC)....
Muhammad Tariq1, Imtiaz Rabbani2, Muhammad Shahbaz Yousaf2, Imdad Ullah Khan1*, Hafsa Zaneb2, Sajid Iqbal3, Alam Zeb Khan1, Shakirullah1, Muhammad Shuaib Khan1, Atta Ur Rehman1 and Mumtaz Ali Khan2
...ous stresses there is an oxidative stress which damages the spermatozoa endogenously. These stresses can be controlled with the inclusion of antioxidants in semen extender at the time of cryopreservation. In the current study, semen from four (n=4) healthy Nili Ravi buffalo bulls was collected through artificial vagina and Gallic acid was added to the semen at 1 µM, 15 µM, 30 µM, 45 µM, 60 µM, and 100 µM. A total of six grou...
Doaa Sh. Mohamed1, Nema S. Shaban2 , Mai M. Labib3, Olfat Shehata4
Semra Okur Gumusova1, Gul Fatma Yarim2, Cuneyt Tamer1,*, Ayris Salt2 and Gokhan Inat3
...the relationship between oxidative stress and cell damage may provide important insight into infection treatment. Previous studies have shown that many viruses induce oxidative cell damage during their replication in mamalian cell culture, but fish viruses has not been well-studied. Infectious pancreatic necrosis (IPN) is caused by infectious pancreatic necrosis virus (IPNV) and it is a viral, fatal and contagious disease of young salmonids and nonsalmonid fis...
Min Li1, Shiwu Deng2*, Yiqian Peng3 and Hong Li2
...ugh mitochondrial and ER oxidative stress pathways. Left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDd) and left ventricular end-systolic diameter (LVESd) of SD rats were measured by echocardiography, and the mRNA expression level of peroxisome proliferator-activated receptor gamma co-activator 1-a (PGC1 a), superoxide dismutase (SOD2) and citrate synthase (Cs) were detected by real-time PCR. Ultrastructural changes of my...
Uzma Jabeen1, Asmat Salim2*, Irfan Khan2, Nadia Naeem3 and Rubina Mushtaq4
... mechanisms, the role of oxidative stress remains obscure, though it is the most probable mechanism for its cardiotoxic effect. The main focus of this study is to analyze the mechanism of renal toxicity caused by this chemotherapeutic drug. As reactive oxygen species are significant regulators of transcription factors and gene expression, this study was aimed at analyzing the expression levels of genes that are induced in response to o...
Jabbar Khan1, Mehwish Jehan1, Zeeshan Mutahir2, Muhammad Rafi1, Muhammad Ismail1, Aamer Abbas1 and Jabbar Tanveer3
...n control group and that oxidative stress, induced by heat stress, may have a negative effect on the availability of Se, which accordingly resulted in reduced synthesis of thyroid hormones. Beside that the concentrations of total protein, cholesterol, albumin and glucose were found significantly higher in Damani breed than control group, indicating that Damani breed had comparatively better adaptive capabilities in preparing the internal physiology and metabol...
Yuechen Li1, Yumo Li1, Xuefeng Zhuang1, Guangfu Lv2, Xiaowei Huang1, Zhe Lin1, Yuchen Wang1* and He Lin1*
Feng Xu, Weijing Fan and Guobin Liu*
...vity, apoptosis rate and oxidative stress level of HUVECs. The low concentrations (25, 50, 100 μmol/L) of rutin had no toxic effect on HUVECs, and the activity of HUVECs was significantly reduced after intervention with high concentrations (200, 400 μmol/L) of rutin. ox-LDL treatment significantly reduced HUVECs activity, CAT and SOD levels,NEXN-AS1 expression (P<0.05), and increased apoptosis rate, MDA level, and miR-410-3p expression (P<0.05). Ru...
Rawda S. Mohamed1,2, Mohammed Y. Matoock2*, Abeer H. Abdelrazek2
Muhammad Kashif Iqbal1*, Khalid Mehmood2,4, Shakeel Ahmed3, Fazul Nabi4, Muhammad Arif Rizwan1, Muhammad Kaleem1, Mushtaq Ahmed1, Abdul Waheed1 and Jiakui Li5
Muhammad Akram1*, Muhammad Imtiaz Shafiq2, Amber Malik3, Farmanullah Khan4, Munir Ahmad Bhinder5 and Muhammad Sajjad6
...of CVDs. To counter this oxidative stress, the most important natural antioxidant defense mechanisms include endogenous glutathione concentration, superoxide dismutase, catalase, and glutathione S-transferase (GST). GST neutralizes reactive oxygen species to regulate physical homeostasis in the body. The target of this study was to evaluate the molecular role of GST genotypic polymorphism involved in the development of CVD. For this case-control study, a total...
Eman A. Al-Shahari1,2, Eman R. ElBealy3, Abdelhalim A. Alkhazendar4 and Abeer A. Alm-Eldeen4*
...res and functions due to oxidative stress and the reduction in the oxidative damage’s tolerance. Quercetin, a flavonoid has the ability to face the oxidative injury through its antioxidant activity. Therefore, the present study was designed to investigate the possible role of quercetin in modulating liver’s function and structure in aged male rats. Forty eight male albino rats (3 and 30 months old) were used. Half of the rats at each age received 2...
