Association of Interleukins to Rheumatoid Arthritis
Association of Interleukins to Rheumatoid Arthritis
Summia Azam1, Sri Rahayu2, Atira Saba3, Afsana Huseynova Anvar4, Muhammad Irfan1*
ABSTRACT
Abstract | Number of Cytokines play key role in number of autoimmune syndromes such as rheumatoid arthritis but exact factor is still not known. But this has been noticed that many pro inflammatory interleukins like IL-1,IL-17,IL-6,IL-18,IL-21,IL-23,IL-32,IL27 ,IL35 and IL-37 are higher in concentration in synovial lining of joints in rheumatoid arthritis patients than the healthy people. Most of them induce the B cell and plasma cells which directly cause the production of antibodies and many of them combine with tumor necrosis factor alpha and cause severe damage. RA cause damage to multiple organs but it severely damages the joints and reduces the life expectancy to 10%. Now researches are going on to down regulate these interleukins in biological control. It has been shown through researches that the down regulation of these interleukins seems to be beneficial in autoimmune diseases.
Novelty Statement | This article novel and useful in describing the detailed mechanisim of association of interleukin to rheumatoid arthritis. Implementing the described mechanisms of neuroimmunology provides possibilities for new treatments.
To share on other social networks, click on any share button. What are these?
