Drug Resistance of Bloodstream Infection with Klebsiella pneumoniae and Detection of drug resistance Genes
Drug Resistance of Bloodstream Infection with Klebsiella pneumoniae and Detection of drug resistance Genes
Jinru Li and Xuemei Zhang*
ABSTRACT
Klebsiella pneumoniae (KP) bacteria are usually present on mucous membranes in animals or in the environment (e.g., water and soil). This work investigated the drug resistance (DR) of bloodstream infection (BSI) KP and the risk factors of infection and prognosis of KP. One hundred and fifty KP strains in our hospital were selected and rolled into a survival group (63 cases) and a death group (87 cases) according to clinical outcomes. According to the type of DR, the strains were rolled into a carbapenem-sensitive KP (CSKP) group (n = 93) and a carbapenem-resistant KP (CRKP) group (n = 57). The DR and resistance genes of KP were analyzed. Logistic regression analysis (LRA) was utilized to explore the risk factors of KP infection and its prognosis. Strains in this work showed DR to most antibiotics, with TEM (20.7%), CTX (14%), and SHV (33.3%) being the main components. Logistic multivariate analysis (LMA) showed that hyperglycemia and history of immune diseases were independent risk factors (IRFs) for CRKP infection (P<0.05), and advanced age, septic shock, bacteremia, and organ failure were IRFs for predicting the death of patients (P<0.05). To conclude KP BSI strains (TEM, CTX, and SHV strains) showed DR to most antibiotics. Hyperglycemia and history of immune diseases were IRFs for CRKP infection; while advanced age, septic shock, bacteremia, and organ failure were IRFs for predicting death.
To share on other social networks, click on any share button. What are these?
