Effect of Aqueous Extract of Cyclotrichium niveum on the Lipophilic Vitamins, Cholesterol and Fatty Acids Profile in the Brain and Kidney of Streptozotocin-induced Diabetes in Rats
Effect of Aqueous Extract of Cyclotrichium niveum on the Lipophilic Vitamins, Cholesterol and Fatty Acids Profile in the Brain and Kidney of Streptozotocin-induced Diabetes in Rats
Mehmet Guvenc* and Mustafa Topaloglu
ABSTRACT
This study examined the influence of Cyclotrichium niveum (CN) extract on fatty acids, ADEK vitamins, cholesterol, and malondialdehyde levels in the brain and kidney of streptozotocin (STZ)-induced diabetes in rats. Thirty-two adults female Wistar albino rats weighing between 250 and 300 g were divided in four groups of eight animals each: control (C) group, diabetic (D) group, CN group, and D + CN group. The control group was fed a standard diet. The diabetic groups received 55 mg/kg of STZ by intraperitoneal (ip) route. The D + CN group received STZ (ip) and 4 ml/kg CN orally. The CN group was administered 20mg/kg of a CN plant extract prepared by prepared by using decoction method. The levels of Alfa-linolenic acid (18:3, n-3) and retinol decreased in the brain (p<0.001) andincreased in the kidney (p<0.01) compared to the control group. , significantly higher vitamin K2 levels were detected in the D+ CN group (p< 0.001) compared to the control group. Vitamin D3 level was drastically lower in the D and CN groups (p<0.001, p<0.01).
To share on other social networks, click on any share button. What are these?
