Evaluation of Cardioprotective Potential of Hydroalcoholic Leaf Extract of Citrullus colocynthis against Doxorubicin Induced Oxidative Stress in Rats
Evaluation of Cardioprotective Potential of Hydroalcoholic Leaf Extract of Citrullus colocynthis against Doxorubicin Induced Oxidative Stress in Rats
Ashira Manzoor1, Imran Ahmad Khan1,2*, Muqadas Sadiq3, Muhammad Omer Iqbal4 and Shaukat Hussain Munawar5
Scavenging activity of leaf extract of C. colocynthis and Ascorbic acid on DPPH.
Effect of hydroalcoholic leaf extract of Citrullus colocynthis on level of oxidative stress in different markers in heart tissues. A, LDH; B, CK-MB; C, troponin-1; D, AST; E, ALT; F, ALP; G, CRP. ns (p > 0.05) did not show any significant reduction. *(p<0.05) showed significant reduction, **(p<0.001) showed highly significant reduction.
(A) Effect of hydroalcoholic leaf extract on histological structure of rats. Heart section from DOX-induced group (B) shows images from heart sections of Extract 250mg/kg + DOX 18mg/kg (C) shows images from heart sections of extract 500 mg/kg + DOX 18mg/kg (D) Shows heart sections from Extract 750mg/kg + DOX 18mg/kg (E)shows images from heart sections of DZR 180mg/kg+ DOX 18mg/kg.
