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In vitro Antiviral Activity of Nigella sativa against Peste des Petits Ruminants (PPR) Virus

In vitro Antiviral Activity of Nigella sativa against Peste des Petits Ruminants (PPR) Virus

Kiran Aqil1, Muti-ur-Rehman Khan2, Asim Aslam2, Aqeel Javeed5, Rizwan Qayyum1, Farooq Yousaf,1 Farkhanda Yasmeen1, Muhammad Luqman Sohail3 and Sajid Umar4,*

1Veterinary Research Institute, Lahore 54000
2Department of Pathology, University of Veterinary and animal Sciences, Lahore 54000
3University College of Veterinary and Animal Sciences, The Islamia University of Bhawalpur, Bhawalpur 63100
4Department of Pathobiology, Pir Mehr Ali Shah Arid Agriculture University, Rawalpindi 46000
5Department of Pharmacology, University of Veterinary and animal Sciences, Lahore 54000

*      Corresponding author: sajncvi@gmail.com

 

Fig. 1.

Effect of extract from N. sativa on morphological changes of Vero cell lines caused by Peste des Petit ruminants virus (PPRV). Microscopic view of the inhibition of N. sativa extracts on cytopathic effect (CPE) formation at about 96 h postinfection by PPRV. A, CPE of Vero cells infected by PPRV; B, Vero cells infected by PPRV and N. sativa extract (100µg/ml); C, Vero cells infected by PPRV and N. sativa extract (50µg/ml).

Fig. 2.

Cell survival percentage for each dilution of of N. sativa extracts used for antiviral and cytotoxicity assay.

Pakistan Journal of Zoology

April

Pakistan J. Zool., Vol. 56, Iss. 2, pp. 503-1000

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