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Study of zeolite as immune stimulant in foot and mouth disease trivalent oil adjuvant vaccine in sheep

Study of zeolite as immune stimulant in foot and mouth disease trivalent oil adjuvant vaccine in sheep

Hiam M. Fakhry and Assem A.A.

Department Of Foot And Mouth Disease, Veterinary Serum And Vaccine Research Institute (Vsvri), Abassia, Cairo, Egypt P.O. Box 131 Svri@Idsc.Gov.Eg

ABSTRACT

Comprehensive sero-immunological study was conducted to reveal the adjuvant's effect of zeolite on the immune response of oil adjuvanted trivalent Foot and mouth disease (FMD) vaccine in sheep. The objective of this study was to evaluate the efficacy of Zeolite (Zeolith UF) as an adjuvant using inactivated trivalent foot and mouth disease virus, to induce protection against foot and mouth disease. This study was conducted in three sheep groups ; the first group was vaccinated intramuscularly (I/M) with trivalent foot and mouth disease zeolite (1 μg/dose) vaccine, The second group was vaccinated with foot and mouth disease oil vaccine and Third group was vaccinated with foot and mouth disease ( oil + zeolite ) vaccine. The cellular immune responses were monitored in different tested groups that revealed the immune responses in sheep continuous with the permissible protective level is (0.280) Delta Optical Density till 8th for zeolite and oil vaccine vaccine while till 10th week post vaccination with foot and mouth disease zeolite + oil vaccine. The humeral immune responses were monitored in different tested groups that revealed the immune responses in sheep vaccinated with trivalent foot and mouth disease vaccine adjuvanted with zeolite similar to results of trivalent foot and mouth disease oil vaccine continue up to 32 week . While addition of zeolite to foot and mouth disease Montanoide oil vaccine increases immune responses up to 40 week . Our results show that the incorporation of zeolite into foot and mouth disease oil vaccine induces an early & long period of high specific protective immune response in sheep. In conclusion we recommended to use a ground zeolite alone or the best to use with oil as a potential adjuvant in foot and mouth disease vaccine .

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Journal of Virological Sciences

1

Vol. 9, Iss. 1, Pages 1-19

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