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A Comprehensive Study on Bioengineering Strategies of Osseous Reconstruction by Using Autogenous Bone Graft with Osteogenic Biologics for Radial Diaphyseal Defect Repair

A Comprehensive Study on Bioengineering Strategies of Osseous Reconstruction by Using Autogenous Bone Graft with Osteogenic Biologics for Radial Diaphyseal Defect Repair

Naveed Hussain1*, Muhammad Arif Khan1, Asim Khalid Mahmood2, Muhammad Yasin Tipu3, Mamoona Chaudhry4, Hamad Bin Rashid1, Haroon Akbar5 and Abdul Aziz6

1Department of Veterinary Surgery, University of Veterinary and Animal Sciences Lahore, 54000, Pakistan
2Department of Small Animal Clinical Sciences, University of Veterinary and Animal Sciences Lahore, 54000, Pakistan
3Department of Pathology, University of Veterinary and Animal Sciences Lahore, 54000, Pakistan
4Department of Epidemiology and Public Health, University of Veterinary and Animal Sciences Lahore, 54000, Pakistan
5Department of Parasitology, University of Veterinary and Animal Sciences Lahore,54000, Pakistan
6Department of Veterinary Clinical Sciences, University of Poonch Rawlakot, 12350, Pakistan
 
*      Corresponding author: nhussain@uvas.edu.pk

Fig. 1.

Changes in temperature (A), pulse (B) and respiration (C) in each group with time points. For temperature and pulse, difference of values of groups A, B, C and D was non-significant (P≥0.05). For respiration, significant difference (P≤0.05) was noted between groups A-C at stipulated days.

Fig. 2.

Changes in WBCs (A), platelets (B), RBCs (C) and Hb (D) in each group with time points. For WBCs, platelets, RBCs and Hb, difference of values of groups A, B, C and D was non-significant(P≥0.05).

Fig. 3.

Changes in serum calcium (A), phosphates (B) in each group with time points. For calcium and phosphates, significant difference of values i.e., * (P ≤ 0.05), **(P ≤ 0.01) of groups A, B, C and D was noted at marked days.

Fig. 4.

Changes in alkaline phosphatase (A), osteocalcin (B) in each group with time points. For alkaline phosphatase and osteocalcin, significant difference of values i.e., *(P≤0.05), **(P ≤ 0.01) of groups A, B, C and D was noted at marked days.

Fig. 5.

Changes in pain score (A), limb deformity (B) in each group with time points. For pain score and limb deformity, significant difference of values i.e., * (P ≤ 0.05), **(P ≤ 0.01) of groups A, B, C and D was noted at marked days.

Fig. 6.

Changes in radius union score (A), histomorphometry (B) in each group with time points. For radius union score and histomorphometry, significant difference of values i.e., **(P≤0.01) of groups A and B was noted at marked days.

Fig. 7.

Examples of Bone healing/callus formation in group A (A), group B (B), group C (C) and group D (D) at end of trial. Best to poor healing noted in group B, C, D and A, respectively.

Fig. 8.

Histomorphometric analysis in group A (A), group B (B), group C (C) and group D (D) at end of trial. Best to poor healing noted in group B, C, D and A, respectively.

Pakistan Journal of Zoology

August

Pakistan J. Zool., Vol. 56, Iss. 4, pp. 1501-2000

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