Cell Cytotoxicity, Antimicrobial, and Mosquitocidal Activity of Prepared Cinnamon Oil Formulations
Cell Cytotoxicity, Antimicrobial, and Mosquitocidal Activity of Prepared Cinnamon Oil Formulations
Hesham A. Mahran1,2*, Shawky M Aboelhadid3, Saad S. Alqahtani4,5, Mohamed Z. Sayed Ahmed4,5
ABSTRACT
The goal of the current study was to create safe, antibacterial formulations based on cinnamon oil that were effective against Culex pipiens adults and pupae. Cinnamon nanoemulsion (CNE) was synthesized and characterized. The binary mixture of cinnamon with sesame oil (CS) was prepared at a rate of one part cinnamon to 3 parts sesame oil. Multiple concentrations from these formulations were prepared and tested against laboratory-reared adults and pupae of C. pipiens. The safety results showed that the ordinary form of cinnamon oil was safer for human skin cell fibroblast and human epidermoid Skin carcinoma than the other forms at high concentrations. Meanwhile, CNE was potent antibacterial activity even at the lowest concentrations. Moreover, CNE showed better pupicidal activity than the other forms with LC50 at 322 ug/mL lower than pure cinnamon oil, 465 ug/mL against pupae. Additionally, the CNE achieved the lowest concentration after 90 min (15.80ug/mL). The high concentration of 69.60ug/mL (LC50) and 135.00ug/mL (LC99) caused toxicity to adult C. pipiens in a short time (15 min). Meanwhile, sesame oil has no toxic effect on adult C. pipens. In conclusion, CNE has better antimicrobial, pupicidal and adulticidal activity against C. pipiens than ordinary and binary mixtures with sesame oil.
Keywords | Culex pipiens, Nanoemulsion, Cinnamon, Sesame, Binary mixture
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March 2023
Vol. 11, Iss. 3, Pages 355-516
