Effect of Quercetin on Rhinitis via Inflammatory Pathway
Yuan Xing, Congming Tan, Yan Luo and Wenjun Liu*
Otolaryngology Head and Neck Surgery, Hong Hui Hospital, Xi’an Jiaotong University, No. 555 Youyi East Road, Beilin District, Xi’an City, Shaanxi Province,710054, China
* Corresponding author: luckydog0730@sina.com
Fig. 1.
The effect of qurecetin and montelukast on sneezing, nasal rubbing and nasal redness in OVA induced allergic rhinitis in rats. A, sneezing; B, nasal rubbing; C, nasal redness. The method described in the material and methods. The data are presented in mean±SEM. *P<0.05,*P<0.01 and ***P<0.001 compared with the AR control group.
Fig. 2.
The effect of quercetin and montelukast on biochemical parameter and spleen weight in OVA induced allergic rhinitis in rats. A, NO; B, histamine; C, spleen weight. The method described in the material and methods. The data are presented in mean±SEM. *P<0.05,*P<0.01 and ***P<0.001 compared with the AR control group.
Fig. 3.
The effect of quercetin and montelukast on pro-inflammatory cytokines and inflammatory mediators in OVA induced allergic rhinitis in rats. A, IL-6; B, INF-γ; C, IL-4; D, IgE. The method described in the material and methods. The data are presented in mean±SEM. *P<0.05,*P<0.01 and ***P<0.001 compared with the AR control group.
Fig. 4.
The effect of quercetin and montelukast on pro-inflammatory cytokines and inflammatory mediators in OVA induced allergic rhinitis in rats. A, IL-6; B, IL-10; C, INF-ϒ; D, IgE. The method described in the material and methods. The data are presented in mean±SEM. *P<0.05,*P<0.01 and ***P<0.001 compared with the AR control group.
Fig. 5.
The effect of quercetin and montelukast on mRNA expression of pro-inflammatory cytokines in OVA induced allergic rhinitis in rats. A, TNF-α; B, IL-1β; C, IL-10; D, INF-ϒ. The method described in the material and methods. The data are presented in mean±SEM. *P<0.05,*P<0.01 and ***P<0.001 compared with the AR control group.