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Identification of Novel Biomarkers MCM2 and GINS2 for Cervical Cancer

Identification of Novel Biomarkers MCM2 and GINS2 for Cervical Cancer

Lei Chu1, Jie Yang2, Zhenshi Chen2, Xiajun Zhang1, Weidong Wu3*, Shaoru Zhang2 and Lihui Wang2*

1Clinical Laboratory, Danyang People’s Hospital of Jiangsu Province, Danyang Hospital Affliated to Nantong University, Jiangsu, China
2Central Laboratory, Danyang People’s Hospital of Jiangsu Province, Danyang Hospital Affliated to Nantong University, Jiangsu, China
3Anesthesiology Department, Danyang People’s Hospital of Jiangsu Province, Danyang Hospital Affliated to Nantong University, Jiangsu, China
 
Lei Chu, Jie Yang and Zhenshi Chen are the co-first authors.
 
*      Corresponding author: njuwanglihui@163.com

Fig. 1.

Protein-protein interaction network of 234 DEGs. 

Fig. 2.
Up-regulate the key modules of gene composition. The red nodes represent up-regulated genes.
Fig. 3.

Survival analyses of GINS2 and MCM2. GINS2 (A) and MCM2 (B) were significantly associated with OS.

Fig. 4.
Expression levels and Pearson correlation analyses between GINS2 and MCM2. Both GINS2 (A) and MCM2 (B) presented high expression levels in CC tissues, but exhibited low expression levels in normal cervical tissues. (C) GINS2 was positively correlated with MCM2.

Pakistan Journal of Zoology

August

Pakistan J. Zool., Vol. 56, Iss. 4, pp. 1501-2000

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