Leverage of Nano-Curcumin Phytosome in Nano-Silicon Dioxide Treated Female Rats
Leverage of Nano-Curcumin Phytosome in Nano-Silicon Dioxide Treated Female Rats
Ghusoon Hasan Jadaan1*, Khalisa K. Khudair2
ABSTRACT
Silica nanoparticles (SiO2NPs) as one of the most productive nano-powder, SiO2NPs cause cytotoxicity and genotoxicity in a variety of cell lines due to oxidative stress. Curcumin Phytosome has antioxidant effects. We aimed to determine how silicon dioxide nanoparticle (SiO2NPs) exposure to female rats affected the oxidative state. Ultraviolet-visible (UV-VIS), scanning electron microscopy (SEM), and Fourier transform infrared (FTIR) spectroscopy were used to investigate SiO2NPs and Curcumin Phytosome nanoparticles (CPNPs). Intense surface plasmon resonance at 1041 nm revealed the formation of silica nanoparticles. The two bands at 326 and 422 nm were ascribed to CPNPs, and SEM examination of SiO2NPs and CPNPs showed that SiO2NPs had an oval shape and a particle’ average size of 64.45±1.18 nm whereas CPNPs had a particle’ average size of 72.80.85 nm. The CCH and cis CH, benzoate trans -CH, the C-O, CH2 and CH3,(C=C),(C=O), CH2 and CH3 which operate as reducing and stabilizing agents were revealed by FTIR analysis of CPNPs. The SiO2NPs’ FTIR spectrum shows two vibrations that can be attributed to SiO2’s Si—O—Si and Si—O vibrations, respectively. Thirty-two Female rats that had reached adult were randomly split into four groups: Control; T1: received oral 200 mg/kg of SiO2 - NPs were gavaged orally to this group of rats. T2: received oral 100 mg/kg of CPNPs and Sio2NPs. T3: received oral 100 mg/kg of CPNPs. We analyzed blood samples of malondialdehyde (MDA), total antioxidant capacity(TAO-C), protein carbonyl(PC), reactive oxygen species (ROS), and gamma-glutamyl transferase concentration(GGT). The results indicated that 200 mg/kg of SiO2 - NPs orally for 4 weeks contributed to a substantial drop in serum TAC-O, an increase in MDA, GGT, PC, and ROS concentration, and attenuation of silica’s oxidative stress status, CP NPs (T3) or SiO2 NPs (T2) administered orally to female rats for four weeks constitutes a case of oxidative stress. The study revealed the protective role of CP NPs against the negative impact of SiO2 NPs. The T3 group that got CP alone saw higher results; CP NPs can be thought of as an antioxidant component.
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