Submit or Track your Manuscript LOG-IN

Polymorphism of SYNE2 Gene and its Association with Litter Size in Small Tail Han Sheep

Polymorphism of SYNE2 Gene and its Association with Litter Size in Small Tail Han Sheep

Zhilong Tian1, 2, Yuqin Wang2, Jishun Tang1,3 and Mingxing Chu1*

1Key Laboratory of Animal Genetics and Breeding and Reproduction of Ministry of Agriculture and Rural Affairs, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China
2College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, Henan 471003, China
3Institute of Animal Husbandry and Veterinary Medicine, Anhui Academy of Agricultural Sciences, Hefei 230031, China

*      Corresponding author: mxchu@263.net 

ABSTRACT

To elucidate the association between polymorphism of SYNE2 and litter size in sheep and provide a new locus for marker-assisted selection of high fecundity traits in sheep. A total of 384 small tail han sheep (STH) were sampled to detect single nucleotide polymorphism (SNP), and Sequenom Mass ARRAY®SNP assay was applied to genotype SNP loci of the SYNE2 gene. In this study, four SNPs were identified and that SNPs were identified that involved in amino acid changes. Population genetic analysis indicated that SYNE2 gene g.73310578G>A, g.73312791A>G showed moderate polymorphism (0.25<PIC<0.5) in Small Tail Han sheep. Furthermore, g.73310578G>A and g.73312791A>G loci were closely linked in STH (r2 > 0.33). Association analysis results showed that g.73310578G>A and g.73312791A>G SNPs significantly affected litter size (P < 0.05). In addition, the litter size of individuals with the combined genotype AA/AG was greater than that of individuals with AA/GG, GA/AG, and GG/AA genotypes in the third parity (P < 0.05). In summary, the SYNE2 gene had a positive influence on the litter size of STH sheep. The linkage of g.73310578G>A and g.73312791A>G could be used in the marker-assisted selection of the litter size of STH.

To share on other social networks, click on any share button. What are these?

Pakistan Journal of Zoology

October

Pakistan J. Zool., Vol. 56, Iss. 5, pp. 2001-2500

Featuring

Click here for more

Subscribe Today

Receive free updates on new articles, opportunities and benefits


Subscribe Unsubscribe