Tasnim Farasat*, Saima Sharif, Farkhanda Manzoor, Muneeza Zafar and Shagufta Naz
...lesterol level and serum insulin were significantly higher (p< 0.05) in proliferative group of diabetic retinopathy, while triglyceride level, HbA1c (%), and low density lipoprotein (LDL) were non-significantly higher (p> 0.05) in diabetic retinopathy groups. To conclude high prevalence of diabetic retinopathy was observed among newly diagnosed diabetic patients....
Farah Ashfaq* and Tasnim Farasat
...cose, serum resistin and insulin of three hundred over weight, obese males and females, 17 to 30 years and 100 comparable control subjects were included. Serum resistin and insulin, fasting glucose, triglycerides and cholesterol were found significantly high in overweight and obese groups as compared to the normal weight group (p<0.01). In overweight group, resistin levels were significantly related with cholesterol,
Rehana Shahida1, Tasnim Farasat1, Shagufta Naz1,* and Shahjahan2
...lammatory cytokines with insulin resistance and the molecular mechanisms involved in the interaction of atherosclerosis and hyperglycemia within the context of chosen pro atherogenic parameters including plasma glucose level, serum levels of insulin, IL-6, and TNF-α. Serum level of thrombomodulin was assessed as a measure of vascular damage. Different demographic parameters as age, BMI, waist /hip ratio, B.P., personal...
Muhammad Saqlain1, Humaira Kalsoom1, Muhammad Fiaz1,2, Abid Mahmood1, Rizwan Aziz Qazi4 ,Waseem Safdar5, Pakeeza Arzoo Shaiq1,Bernard M.Y. Cheung3 and Ghazala Kaukab Raja1,*
...mportant risk marker for insulin resistance, obesity, diabetes, and metabolic syndrome (MetS). In this study the association of Ala54Thr polymorphism with MetS and its risk components was studied in a local Pakistani population. MetS subjects and controls were recruited from out-patient departments of Pakistani hospitals. Ala54Thr genotyping of 200 MetS patients and 200 healthy controls was performed using a PCR-RFLP. Genotype and allele frequencies were calcu...
Faiza Hassan1, Mubshara Saadia1,*, Muhammad Sher1, Mian Anjum Murtaza2, Muhammad Arshad3,Asam Riaz4 and Mahmood Ahmad Khan5
...sativa oil; NSO) and insulin. Alloxan induced diabetic rats were post treated with plant extracts (150 mg/kg) and serum samples were collected from overnight fasted diabetic rats on day 15 to observe thepercent changes in blood glucose levels and lipid profile. Garlic extracts have shown the significant (p<0.001) hypoglycemic activity with no considerable effect on mean body weight of rats (ns, p>0.05) as compared to diabetic rats. The AGE treatment ...
Mian Sajjad Ahmad1, Somia Iqtadar1, Sami Ullah Mumtaz1*, Zafar Niaz1, Iqra Waheed2 and Sajid Abaidullah1
...d with hyperglycemia and insulin resistance. To determine the frequency of impaired glucose tolerance in obese patients. This Cross Sectional study was carried out in North Medical Ward, King Edward Medical University/ Mayo Hospital Lahore for 6 months i.e. January to June 2014. Total 160 obese patients visiting outpatient department of North Medical Ward, Mayo Hospital Lahore for 6 months were included by non-probability purposive sampling. Patients aged 15-7...
Selçuk Kaplan1,* and Sertaç Atalay2
...mine the polymorphism of insulin-like growth factor 1 (IGF1) and leptin (LEP) genes in Kivircik crossbred ewes. Therefore, IGF1/BfoI and Lep/BcnI polymorphisms were examined by polymerase chain reaction- restriction fragment length polymorphism method. The single nucleotide polymorphism (SNP) in the regulatory region of the IGF1 gene was detected by amplification of the 294 bp region using specific primers and cleavage with t...
Shireen Ihsan Izzaddeen1 and Ali Kaygısız2,*
...nine, phosphor, calcium, insulin, total T3, total T4, albumin, GH and globulin concentrations did not differ between the groups (P>0.05). Essential laurel oil containing whole milk, on the other hand, lowered serum triglyceride concentration (P<0.05). Altogether these results suggested that the consumption of laurel essential oil (600 mg/day) containing whole milk by calves might have positive influences on their health parameters compared to the control...
Chuanpeng Zhou1, Heizhao Lin2,*, Zhong Huang2, Jun Wang1, Yun Wang1 and Wei Yu2
...vely (P<0.05). Plasma insulin content was significantly lower at 1, 3, 6 and 12 h after oral administration of both doses of glucose (P<0.05). Compared to the low dose of glucose group, the high dose of glucose group has lower plasma glucagon content 12 h after oral administration, higher muscle and hepatic glycogen contents 6 h after oral administration (P<0.05). The hepatic pyruvate kinase activity peaked 6 h after oral administration in both...
Lili Zhang, Yuanxiao Wang, Yili Kong, Hussain Ahmad, Rui Yan, Li Dong, Jingfei Zhang and Tian Wang*
...s (P<0.05). The serum insulin levels of the IUGR pigs were significantly lower (P<0.05) than the NBW pigs at 28 and 66 days of age. The serum leptin level was significantly higher (P<0.05) in the IUGR pigs at 28 days of age while it decreased significantly (P<0.05) at 160 days of age as compared to the NBW pigs at the same age. Fatty acid composition of the longissimus dorsi muscle was not affected by IUGR (P>0.05). Furthermore, b*, L*...
Farhat Ijaz1, Rana Khurram Aftab2*, Samia Jawed3
...etes mellitus (T2DM) and insulin resistance (IR) are linked to each other. Obesity and T2DM are states of low-grade chronic inflammation, which result in increased levels of inflammatory markers such as C-reactive protein (CRP), interleukins 6 (1L-6) and tumor necrosis factor alpha (TNF-α). Relation of TNF-α with obesity induced IR and T2DM is unclear as results obtained from different studies are very controversial.
Objective: T...
Salma Javed1, Muhammad Fiaz Khan1, Irfan Ullah2, Sadia Tabassum1,*
...s these factors increase insulin resistance of the body cells and act as risk factors for developing the disease. Family history of diabetes having OR=3.35, 95% Cl=2.98-4.20, and P<0.0001 was also found having a strong association with the condition due to the heritability of the disease. The results concluded that the incidence was high among people with a positive family history of diabetes in first-degree relatives, housewives, and retirees of District B...
Sajida Sabahat1, Asif Nadeem1,*, Maryam Javed1, Muhammad Yasir Zahoor1, Abu Saeed Hashmi1, Ghulam Yasein2 and Ghulam Abbas1
Yan-Guo Han, Yu-Qing Han, Jia-Yuan Wu, Jia Guo, Ri-Su Na, Yan Zeng, Guang-Xin E, Yong-Ju Zhao and Yong-Fu Huang*
... growth hormone (GH) and insulin-like growth factor 1 (IGF-1) concentrations were detected by radioimmunoassay. The offspring lambs in T group showed significantly lower serum SS and higher PRL concentrations than those in the control group, and there were no difference between T group and the control group in terms of serum GH and IGF-1 concentrations. There was a significant negative correlation between offspring lambs serum SS and GH, IGF-1, PRL concentrati...
Ahmed Weli Hussein Osman1,2, Rakibul Islam1, Md. Bazlar Rashid1, Abdiaziz Idiris Mohamud2,3* and Pravin Mishra4
Nanoparticle Tactics for the Oral Delivery of Insulin in Alloxan-Induced Hyperglycemia in Rat (Rattus norvegicus domestica) Model
...on of peptide drugs like insulin through the oral avenue specially the gastro-intestinal tract represents the great challenges. Polymeric nanoparticles are suitable colloidal carriers for insulin delivery. The current study was carried out to evaluate nanoparticle tactics for the oral delivery of insulin in the alloxan-induced hyperglycemia in rat model. Twenty male rats of age four months...
Ying Liu1, Shankun Liu1, Hui Wang2 and Weihua Su2,*
...1) enhanced the level of insulin, hepatic glycogen as compared to GDM control group rats. Caffeic acid significantly (P<0.001) increased the level of antioxidant enzymes in the liver and pancreas tissue at dose dependent manner. Our finding clearly supported the beneficial effect of caffeic acid on not only the diabetes mellitus, but also alleviating Gestational diabetes mellitus.
...
Ramazan Erdogan1*, Mikail Tel2, Vedat Cinar2 and Ragip Pala2
...ansporter-4 (GLUT-4) and insulin receptor substrate-1 (IRS-1) in adipose tissue of rats fed on zinc picolinate supplement diet. A total of 42 male 8-week-old Wistar albino rats were randomly divided into 6 groups, each of seven; Control (C), Zinc picolinate (ZP), Chronic exercise (CE), Chronic exercise+Zin picolinate (CE+ZP), Acute exercise (AE), Acute exercise+Zinc picolinate (AE+ZP). Rats were subjected to a 30-min running test 5 days a week for 6 weeks afte...
Amr N. El-Shahat1, Refaat G. Hamza1,*, Ashraf M. Mounir1 and Madeha N. Al-Seeni2
...eases in level of HDL-C, insulin and showing elevation in GSH level and SOD and CAT activities of the liver and kidney of gamma-irradiated treated rats compared to irradiated group.It was suggested that the biochemical and antioxidant amelioration observed in GFJ treated irradiated rats might be due to the antioxidant potential effects of graviola active constituents.
...
A.M. Abdul Azeem, Ashraf M. Mounir and Amr N. El-Shahat*
... in the concentration of insulin, total thyroid hormones triiodothyronin and thyroxine, leutinizing hormone, testosterone and testicular antioxidant parameters (glutathione content , the activity of xanthine dehydrogenase, superoxide dismutase and catalase) in the group of alloxan (150 mg/kg B.WT)-administrated rats as compared to control group. Treatment of diabetic rats with GPSDP (1 g/kg B.Wt/day/ 8 weeks) resulted in significant reduction of glucose level ...
Ziyue Qin1, Ali Mujtaba Shah2, 3, Qing Zhu1, Yan Wang1, Diyan Li1, Gang Shu4, Yaofu Tian1 and Xiaoling Zhao1*
...cose tolerance test, and insulin sensitively test (OGTT and IST) in the fast- (FG) and slow- (SG) growing broilers. Each of 120 one-day-old males was raised in 10 batteries, respectively. In the OGTT test, ten broilers on d 42 fasted 12 h from each stock were randomly assigned into two groups: glucose and vehicle, respectively. The glucose group received a glucose syrup by oral gavage (2 g/kg BW), while the vehicle group received an equivalent volume of normal...
Rana A. Ali1, Abd-Elraheim A. Elshater2, Heba A. Mohammed3*, Mahmoud Elshazly4
...holesterol, glucose, and insulin in the STZ group, while, the other treated groups showed an improvement in such enzymes. Histopathology, STZ induced necrosis, and degenerative changes with vacuolation. Treated groups displayed moderate to mild vacuolation and congestion of the blood vessels. Conclusion: The experience showed the effectiveness of the laser and its few side effects in treating diabetic rats.
Keywords | Diabetes mellitus, Laser, Biochemi...
Adimabua Mike Moemeka1, Ufuoma Godstime Sorhue1*, Sylvanus Ikenna Omeje2, Lawrence Bratte2, Raphael Onainor1, Okpara Oghenesuvwe2
Aysam Fayed1, Mohga A Ibrahem2, Soha A. Hassan3, Mohammed Abdalla Hussein4*, Tamer Roshdy1
...ed to determine glucose, insulin, leptin, TC, TG, HDL-C, ALT, AST, MDA, TNF-α, PCO. The HFD administrated rats resulted in increased total body weight, glucose, insulin, leptin, cholesterol, triglycerides, MDA, ALT, AST, TNF- α and PCO levels, as well as SREBP1 gene expression, according to the findings. However, our findings revealed a significant reduction in HDL-C, GSH, CAT and PON 1 enzyme levels, the express...
Muhammad Sajid Hamid Akash1*, Hina Sharif1, Kanwal Rehman2, Sumbal Rasheed1 and Shagufta Kamal3
...cose, reduction in serum insulin, rise in insulin resistance and alteration of carbohydrate metabolizing biomarkers when compared with unexposed rats. Arsenic concentration was found to be significantly high in liver tissues of ATO exposed rats. Contrarily, RSV was found to be effective in regulating normal glycemic level, insulin tolerance, and metabolic biomarkers. Hence, it was found th...
Jiahua Peng1,2, Shiyao Hua3* and Qian Wu4
...ing blood glucose, serum insulin and insulin sensitive index changes were analyzed. The RT-PCR method was used to detect ovarian tissue TNF alpha and the level of IL-6 gene expression; Western blot was used to detect the changes in the expression levels of IKKβ and NF-κB protein expression. The results of fasting blood glucose and serum insulin test showed that DHEA could signif...
Saydat Saad Abd El-Megeed1, Walaa Yehia El-Sayed1*, Tarek Khamis2
...r (PPAR) –γ, insulin-like growth factor 1 (IGF1), PPAR-α, glucagon-like peptide 1 (GLP-1) in pancreatic homogenate, and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) in pancreatic homogenate which is also a dose- and time-dependent manner. Thus, the study has demonstrated that the combination of Empagliflozin and ZnO NPs could be a promising therapy to alleviate the progression of diabetes.
Keywor...
USMAN AHMAD*1, AMTUL JAMIL SAMI1, MADEEHA KARAMAT1, MADEEHA KHALID1, FAIZAN NAEEM2 & MUHAMMAD JAMIL YOUSAF3
...patches of hydrogels for insulin delivery. Psyllium, a natural polysaccharide, is a dietary fiber and widely utilized in gel forming. To study the structural aspects of these various polymeric webs were categorized with FTIR, SEM and release related experiments such as swelling kinetics, swelling ratio and drug kinetics and the impact of pH on the release of insulin from medicated hydrogels has been concentrated to evaluate ...
Jian-Cheng Zhai1,2, Sheng-Nan Wang1,3, Qiang-Hui Wang1, Yan-Ling Xia1, Wei-Shi Liu1, Ya-Jie Yin4 and He-Ping Li1*
Waheed Khan1, Muhammad Ajmal Khan2, Bakhtawar Khan1*, Aftab Amin3, Muhsin Ali4, Awais Farid, Ali Hazrat5 and Muhammad Yahya5
...lute or relative lack of insulin synthesis or activity. At present, the existing diabetes mellitus drugs have many adverse reactions. Therefore, it is needed to investigate novel methods to improve DM treatment. Thus plant-based management could be a possible antidiabetic strategy. The objective of the most recent study was to assess Verbascum thapsus’s ability to combat hyperlipidemia and diabetes. Mice were given an intraperitoneal injection of alloxan...
Asmaa A. Darwish*, Adel M. El-Kattan, Mona A. Mahmoud, Mohamed T. Ragab, Amani A. Hafez
...cytokine, anti-oxidants, insulin, T3, and T4 levels. The iron profile of infected animals was characterized by a significant (P˂0.05) hypoferremia, hyperferritinemia, and hypotransferrinemia. The estimated pro-inflammatory cytokines and APPs yielded high sensitivity and specificity values in both infected species, but IL-1β, IL-6, and Fb had the highest likelihood ratios in infected sheep and IL-1β and IL-1α had the highest likelihood ratios i...
Yufang Liu1,2, Guiling Cao3, Yujing Xie3 and Mingxing Chu1*
...d hormone synthesis, and insulin secretion. Online tool was used to predict the function of DEGs, the results showed that the CYP11A1 gene might regulate the GDF9 and other prolificacy-associated markers in ovary organs of goats, thereby affecting the development of puberty. The expression of various genes and the transduction of hormone secretion signals, improving the reproduction of goats....
Amina Rahat1, Zahin Anjum1*, Sehlina Zehra2, Fatima Umal Baneen3 and Rabia Chishti1
...sis, metabolic syndrome, insulin resistant syndrome, and high level of cholesterol, nerve tension problems; it stops hair fall and boost’s immune system. Based on the results of this study, it can be concluded that almost all the plant extracts showed potential antibacterial, insecticidal and antifungal activities against different. The research has focused on the potential therapeutic efficacy of AliumSativum, NigelaSativa, and Plantago Ovata in the tre...
Beenish Shahid1* and Muhammad Ijaz Khan2
...adotrophin (2 IU/ml) and insulin (0.12 IU/ml) alone or together in different combinations at intervals of 8, 16 and 24 h of incubation period during in vitro maturation on buffalo oocyte. The supplementation of TCM-199 with E2+rhFSH showed a highly significant increase in the diameter and maturation of oocytes (P<0.0001), as a greater number of the oocytes progressed to the metaphase II stage, and a lower proportion of the oocytes became degenerated (P<0...
Ali Mosa Rashid Al-Yasari1, Zahid I. Mohammed2, Haider S. Almnehlawi3,4, Ali F Bargooth5, Nawar Jasim Alsalih1, Huda F. Hasan6*, Mohenned A Alsaadawi1
...r fasting blood glucose, insulin, and glucagon. Animals were sacrificed on day 28, and tissues were collected for immunohistochemical identification of pancreatic cells that produce insulin and glucagon. Based on our results, none of the research parameters significantly differed across the groups on day 0. Days 1 through 28 showed that STZ-Diabetes group had the uppermost blood glucose level with lowermost blood
Abroo Fatima Qazi* and Din Muhammad Shaikh
... level and rise in serum insulin as compared to positive control group (P < 0.001). At the same time, they showed significantly increased expression of insulin gene along with transcription factor PDX1 in group A (P < 0.001). It was concluded that the effect of appropriate dosage of O3FAs on the transactivation of insulin gene by expressing PDX1 can be a new therapeutic strategy in m...
Qing Cao1, Wei Jiao2, Huihui Lu1, Jing Zhang2, Meiling Ren3, Yan Xu1* and Shuyang Hu1*
...a lower level of fasting insulin (FINS) in serum (all P < 0.05); levels of plasma fibrinogen (Fb) and D-dimers (D-D) in serum of patients in the hyperglycemia group were much higher than those in the hypoglycemia group, while serum plasma prothrombin time (PT) and activated partial thromboplastin time (APTT) were much shorter than those in the hypoglycemia group (all P < 0.05). Thrombus precursor protein (TpP), P-selectin (Ps), maximum platelet aggregati...
Qing Cao1, Wei Jiao2, Huihui Lu1, Jing Zhang2, Meiling Ren3, Yan Xu1* and Shuyang Hu1*
...a lower level of fasting insulin (FINS) in serum (all P < 0.05); levels of plasma fibrinogen (Fb) and D-dimers (D-D) in serum of patients in the hyperglycemia group were much higher than those in the hypoglycemia group, while serum plasma prothrombin time (PT) and activated partial thromboplastin time (APTT) were much shorter than those in the hypoglycemia group (all P < 0.05). Thrombus precursor protein (TpP), P-selectin (Ps), maximum platelet aggregati...
Xiangmei Chen, Burie Bao* and Mo Degema
...ted haemoglobin (HbALc), insulin (INS) and glucose (GLUC3) as well as the protein expression and mRNA levels of sodium-glucose co-transporter 2 (SGLT2) and glucose transporter 2 (GLUT2) were used to study the mechanism of the hypoglycaemic effect of CPP on diabetic rats. We found that camel placenta produced no meaningful changes in the weight of hyperglycaemic rats or the weight of the liver, kidney, or pancreas. After STZ modelling, the blood glucose levels ...
Rehana Shahida1, Shagufta Naz1*, Tasnim Farasat1, Saima Sharif1, Shah Jahan2 and Farkhanda Manzoor1
...elationship of IL-6 with insulin resistance. The patients visiting Amin Hayat Memorial Diabetic Center, Lahore from (January 2017 to October 2017) the subjects following WHO criteria of IGT and Diabetes were included. Demographic parameters as age, body mass index, waist/hip ratio, blood pressure, and socioeconomic status were recorded. Proatherogenic parameters like plasma glucose level, serum levels of insulin, thrombomodu...
Yanfei Cai1, Jiahong Feng1 and Wanlong Zhu1,2,3*
...ood, then studied animal insulin sensitivity, blood pressure, blood biochemistry, routine blood, inflammatory response, and liver fat accumulation, etc. We found that T. belangeri had no metabolic disorders such as insulin resistance, hypertension, or hyperlipidemia after obesity, and there were also no typical obesity complications such as diabetes, inflammation, or fatty liver. To sum up, we suggest that T. belangeri can b...
