Evaluation of Arabian Camels Milk’s Ability in Ameliorating Glucose Homeostasis in STZ-induced Diabetes in Adult Male Rats
Evaluation of Arabian Camels Milk’s Ability in Ameliorating Glucose Homeostasis in STZ-induced Diabetes in Adult Male Rats
Ali Mosa Rashid Al-Yasari1, Zahid I. Mohammed2, Haider S. Almnehlawi3,4, Ali F Bargooth5, Nawar Jasim Alsalih1, Huda F. Hasan6*, Mohenned A Alsaadawi1
ABSTRACT
It is generally known that the milk of Arabian camels helps to maintain good health and is commonly applied in conventional medicine to cure a number of ailments. In this investigation, we delivered fresh milk from Arabian camels to adult male rats that had been given STZ to induce diabetes. Three groups of ten adult male Albino rats each were created at random from the thirty total animals. Control group was given ordinary food and free water, the STZ-Diabetes group received one (ip) injection of streptozotocin (40 mg/kg), and the STZ-diabetes+Camels’ Milk group received a STZ injection (40 mg/kg) along with daily (ad libitum) bottled camel milk for 28 days. Zero time, one day, one week, two weeks, three weeks, and day 28 following STZ injection were used to monitor fasting blood glucose, insulin, and glucagon. Animals were sacrificed on day 28, and tissues were collected for immunohistochemical identification of pancreatic cells that produce insulin and glucagon. Based on our results, none of the research parameters significantly differed across the groups on day 0. Days 1 through 28 showed that STZ-Diabetes group had the uppermost blood glucose level with lowermost blood insulin among the study groups as a result of the induction of diabetes. Comparing the STZ group to the control and camels’ milk groups, the blood glucagon level was the highest in the STZ group. Comparing the diabetes group to other groups, immunohistochemical analysis revealed a significant reduction in insulin secretion cells. In contrast, considerably more glucagon-producing cells were seen in the STZ group. Data from the camel milk group demonstrated its capacity to lessen the effects of STZ, but it did not completely eliminate the consequences of diabetes as there were still some disparities between the camel milk group and the control group. In conclusion, although camel milk didn’t completely restore the body’s health condition, our research showed that it significantly ameliorated the adverse effects caused by diabetes.
To share on other social networks, click on any share button. What are these?
